• Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia 

      Siljan, William Ward; Holter, Jan Cato; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Aukrust, Pål; Mollnes, Tom Eirik; Heggelund, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-24)
      Background:<br> The inflammatory response to community-acquired pneumonia (CAP) is orchestrated through activation of cytokine networks and the complement system. We examined the association of multiple cytokines and the terminal complement complex (TCC) with microbial aetiology, disease severity and shortterm outcome.<br> Materials and methods: <br>Plasma levels of 27 cytokines and TCC were ...
    • Low levels of immunoglobulins and mannose-binding lectin are not associated with etiology, severity, or outcome in community-acquired pneumonia 

      Siljan, William Ward; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Skattum, Lillemor; Bosnes, Vidar; Garred, Peter; Frøland, Stig Sophus; Mollnes, Tom Eirik; Aukrust, Pål; Heggelund, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-05)
      <p><i>Background - </i>Disease severity and outcome in community-acquired pneumonia (CAP) depend on the host and on the challenge of the causal microorganism(s). We measured levels of immunoglobulins (Igs) and complement in 257 hospitalized adults with CAP and examined the association of low levels of Igs or complement to microbial etiology, disease severity, and short-term and long-term ...
    • Patient characteristics in sepsis-related deaths: prevalence of advanced frailty, comorbidity, and age in a Norwegian hospital trust 

      Torvik, Marianne Ask; Nymo, Stig Haugset; Nymo, Ståle Haugset; Bjørnsen, Lars Petter Bache-Wiig; Kvarenes, Hanne Winge; Ofstad, Eirik Hugaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-09)
      Objective - To examine the prevalence of advanced frailty, comorbidity, and age among sepsis-related deaths in an adult hospital population.<p> <p>Methods - Retrospective chart reviews of deceased adults within a Norwegian hospital trust, with a diagnosis of infection, over 2 years (2018–2019). The likelihood of sepsis-related death was evaluated by clinicians as sepsis-related, possibly ...
    • Revisiting the obesity paradox in heart failure: Per cent body fat as predictor of biomarkers and outcome 

      Aimo, Alberto; Januzzi, James L.; Vergaro, Giuseppe; Clerico, Aldo; Latini, Roberto; Meessen, Jennifer; Anand, Inder S.; Cohn, Jay N.; Gravning, Jørgen A.; Ueland, Thor; Nymo, Ståle Haugset; Brunner-La Rocca, Hans-Peter; Bayes-Genis, Antoni; Lupón, Josep; de Boer, Rudolf A.; Yoshihisa, Akiomi; Takeishi, Yasuchika; Egstrup, Michael; Gustafsson, Ida; Gaggin, Hanna K.; Eggers, Kai M.; Huber, Kurt; Tentzeris, Ioannis; Ripoli, Andrea; Passino, Claudio; Emdin, Michele (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-01)
      <i>Aims</i> - Obesity defined by body mass index (BMI) is characterized by better prognosis and lower plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure. We assessed whether another anthropometric measure, per cent body fat (PBF), reveals different associations with outcome and heart failure biomarkers (NT-proBNP, high-sensitivity troponin T (hs-TnT), soluble suppression ...
    • Secreted frizzled related protein 3 in chronic heart failure: Analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA) 

      Askevold, Erik Tandberg; Gullestad, Lars; Nymo, Ståle Haugset; Kjekshus, John; Yndestad, Arne; Latini, Roberto; Cleland, John G.F.; McMurray, John J.V.; Aukrust, Pål; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-19)
      Background We have previously demonstrated an association between increased sFRP3 expression and adverse outcome in a population of HF irrespective of cause and left ventricular ejection fraction. In this study we evaluated the prognostic value of sFRP3 in older patients with chronic systolic HF of ischemic origin. <p>Methods We evaluated sFRP3, by tertiles, as a risk factor for the primary ...
    • Serum neutrophil gelatinase-associated lipocalin (NGAL) concentration is independently associated with mortality in patients with acute coronary syndrome 

      Nymo, Ståle Haugset; Hartford, Marianne; Ueland, Thor; Yndestad, Arne; Lorentzen, Erik; Truvé, Katarina; Karlsson, Thomas; Ravn-Fischer, Annica; Aukrust, Pål; Caidahl, Kenneth (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-08)
      <i>Background</i> - Circulating neutrophil gelatinase-associated lipocalin (NGAL) concentration increases in cardiovascular disease, but the long-term prognostic value of NGAL concentration has not been evaluated in acute coronary syndrome (ACS). We examined the association between NGAL concentration and prognosis in patients with ACS after non-ST-elevation myocardial infarction (NSTEMI) or ...
    • YKL-40 (Chitinase-3-Like Protein 1) Serum Levels in Aortic Stenosis 

      Arain, Fizza Kanwal; Abraityte, Judita Aurelija; Bogdanova, Mariia; Solberg, Ole Geir; Michelsen, Annika; Lekva, Tove; Aakhus, Svend; Holm, Sverre; Halvorsen, Bente; Finsen, Alexandra; Vinge, Leif Erik; Nymo, Ståle Haugset; Espeland, Torvald; Ranheim, Trine; Aukrust, Pål; Vaage, Ingvar Jarle; Auensen, Andreas; Gullestad, Lars; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-23)
      <p><i>Background:</i> Identification of novel biomarkers could provide prognostic information and improve risk stratification in patients with aortic stenosis (AS). YKL-40 (chitinase-3-like protein 1), a protein involved in atherogenesis, is upregulated in human calcific aortic valves. We hypothesized that circulating YKL-40 would be elevated and associated with the degree of AS severity and outcome ...